Is autorun CD enable in your system?
-if not, you can open the CD from my computer, dobule click it. If it still can't install, you can try right click one the CD drive> open> manga_studio_3_ex_CD1>Manga Studio3_EX> double click on the setup.exe
Do you have any kind of anti-viurs program running in the background?
-if yes, disable it, restart your computer and try install again
